Thanks for this. I was taking metformin for around a year, although not consistently but stopped a couple of months ago due to some concerns. This reinforces that decision. Looking forward to the results of the TAME trial but this isn't encouraging.
Metformin synergizes with rapamycin in ITP mouse trials though (the mice with highest lifespans used 14 ppm rapamycin + metformin and that's not even using the highest doses). A lot of ROS is produced by Complex I (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680180/)
Thanks for this. I was taking metformin for around a year, although not consistently but stopped a couple of months ago due to some concerns. This reinforces that decision. Looking forward to the results of the TAME trial but this isn't encouraging.
Thank you for this essay on metformin. Good science! May I please have a link to a copy of your CV?
Metformin synergizes with rapamycin in ITP mouse trials though (the mice with highest lifespans used 14 ppm rapamycin + metformin and that's not even using the highest doses). A lot of ROS is produced by Complex I (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680180/)