3 Comments

Thanks for this. I was taking metformin for around a year, although not consistently but stopped a couple of months ago due to some concerns. This reinforces that decision. Looking forward to the results of the TAME trial but this isn't encouraging.

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Thank you for this essay on metformin. Good science! May I please have a link to a copy of your CV?

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Metformin synergizes with rapamycin in ITP mouse trials though (the mice with highest lifespans used 14 ppm rapamycin + metformin and that's not even using the highest doses). A lot of ROS is produced by Complex I (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680180/)

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